Keep this medicine out of the sight and reach of children. Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. CLS is a serious, potentially fatal condition causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint (low blood pressure). %PDF-1.3 % FDA Approved: No 0000004761 00000 n According to the information that AstraZeneca and the University of Oxford presented to the United Kingdom's vaccine regulatory agency, this vaccine contains: The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. The expiry date refers to the last day of that month. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. Getty Images. It is a summary of information about the drug and will not tell you everything about the drug. The solution is colourless to slightly brown, clear to slightly opaque. The majority of these cases occurred within the first four weeks following vaccination. 0000132090 00000 n hb```(1A;B% What COVID-19 Vaccine AstraZeneca is and what it is used for, What you need to know before you are given COVID-19 Vaccine AstraZeneca, How COVID-19 Vaccine AstraZeneca is given, How to store COVID-19 Vaccine AstraZeneca, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of COVID-19 Vaccine AstraZeneca, Package leaflet: Information for the recipient, nationalarchives.gov.uk/doc/open-government-licence/version/3. 0000015573 00000 n This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection JZD| Solution for injection. 548 0 obj <> endobj After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. /Info 87 0 R [recombinant]) [COVID-19 Vaccine AstraZeneca]with other vaccines have not been evaluated. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. We use some essential cookies to make this website work. brain, liver, bowel, spleen). Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. This means that a COVID-19 vaccine cannot make you sick with COVID-19. The AstraZeneca vaccine is based on time-tested technology that employs a harmless cold virus (called adenovirus) that has been genetically modified to stimulate an immune response against the coronavirus. This includes any possible side effects not listed in this leaflet. Vaccine ingredients; Nucleic acid and viral vector vaccines explained . Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety Younger patients may be more likely to experience anaphylaxis. If you get any side effects, talk to your doctor, pharmacist or nurse. <]/Prev 553136>> Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. This product contains genetically modified organisms (GMOs). Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. Like all medicines, this vaccine can cause side effects, although not everybody gets them. Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T 6`CA$'i$W30120ma`$p@ J To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. 0000006617 00000 n AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). On his way to a meeting to present . See the end of section 4 for how to report side effects. You can change your cookie settings at any time. 410 0 obj <>stream Netherlands. You may access the guidance document here. 0000100169 00000 n By reporting side effects you can help provide more information on the safety of this vaccine. AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. This explainer is more than 90 days old. %PDF-1.7 % 0000098956 00000 n If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. Do not freeze. To help us improve GOV.UK, wed like to know more about your visit today. Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. How COVID-19 Vaccine AstraZeneca is given 4. 0 Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. hb```b``9 |Abl,=@00M(P~. AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. hbbd``b` $HpXAv DL) Vaccines are generally very safe and their study involves a rigorous process. %PDF-1.7 % 0000082759 00000 n 18 June 2021. _:);~6`Tgx_A/`d`G,~#V?]|j~^9jfWu?g8uN~Tg'~^'G%|S>#Z{,gcOgg"Q27v}IyaM|"6ocj Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. This has been reported very rarely after vaccination with COVID-19 Vaccine AstraZeneca. The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. This article has been translated from its original language. 0000006047 00000 n 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. xref 0000083589 00000 n The AstraZeneca vaccine is based on an adenovirus that circulates in chimpanzees . Dont worry we wont send you spam or share your email address with anyone. *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. x]n@FwezA"+q*z B-csD"%;>3a,7Mg>;M1crUukGavi%. 581 0 obj <>stream (see section 2. The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. After withdrawing the final dose, some liquid may remain in the vial. z(2$bW*; ! % 0000098136 00000 n Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. Well send you a link to a feedback form. 779 0 obj <> endobj The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. {zzZ`ntK?D6r|D#T$* TGBKz. The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. b t@f&!+:eez8YY8.j 7 COVID-19 Vaccine AstraZeneca contains sodium and alcohol). Treatment for: Prevention of COVID-19. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. >> A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. According to the vaccine's safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following: headache (52.6%) fatigue . Like any vaccine, the COVID-19 vaccines do come with potential side effects. EDTA is not listed as an ingredient in the Johnson &. Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. It is a proven, safe and relatively old approach. Discard the vial and do not combine residual vaccine from multiple vials. WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. That way, when a person is exposed to COVID-19, its immune system will recognize the part of the virus that has those spike proteins and will know how to how to fight it. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 0000098877 00000 n 0000001605 00000 n Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . Published March 31, 2021 Updated Aug. 1, 2021. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. In line with the WHO Prioritization Roadmapand and the WHO Values Framework older adults, The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. 0000007231 00000 n Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. Efficacy. %%EOF People with a history of severe allergic reaction to any component of the vaccine should not take it. Some excipients are added to a vaccine for a specific purpose. Vaccine efficacy tended to be higher when the interval between doses was longer. 346 65 Oxford-AstraZeneca COVID-19 vaccine efficacy. << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. 0000004537 00000 n . 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream 0000055862 00000 n %%EOF 0000018147 00000 n AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. It is not yet known how long you will be protected for. Once the vaccine has undergone Phase 3 testing, the manufacturer can apply for a license from regulatory authorities (like the FDA in the US) to make the vaccine available for public use. Once this enters the body, it tells your cells to make copies of the spike protein. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. 0000088968 00000 n Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. stream 0000008310 00000 n Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. Andrew Pollard was in a French taxi when he realised what was coming. Keep this leaflet. are no data yet for Omicron. Vaccine Excipient Summary Excipients Included in U.S. 0000000016 00000 n SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. Seek immediate medical attention if you develop these symptoms in the days following vaccination. 0000019840 00000 n The AstraZeneca vaccine is made from an adenovirus that has been changed in the lab so it can't cause harm. hb```f``m ,@Q"12/L1T43xYsAC:?X\r()c .O8:g] l TB;]@< -ll`]@m EX The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international ]0[ After vaccination, the surface spike protein is produced, priming the immune system to attack the virus if it later infects the body, protecting it against COVID-19. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. In countries with ongoing Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. 3. With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. 0000106271 00000 n Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. $x >HdA@; 0000009792 00000 n 0000002960 00000 n 0000021326 00000 n Health information in your inbox, every other week. Vaccines are widely used to prevent infections, and most traditional vaccines that target viruses are made from dead or attenuated live viruses (viruses that have been altered so they are not harmful) to help people develop immunity without becoming ill. Available for Android and iOS devices. It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks. The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. 0000001732 00000 n Some cases were life-threatening or had a fatal outcome. Contents of the pack and other information 1. We also use cookies set by other sites to help us deliver content from their services. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: Any unused vaccine or waste material should be disposed of in accordance with local requirements. 0000024916 00000 n endstream endobj startxref 0 %%EOF 72 0 obj <>>> endobj 95 0 obj <> stream This webpage was updated on 13 June 2022 to ensure consistency of formatting. Can they overcome their checkered past? Spills should be disinfected using agents with activity against adenovirus. O'`` r/ RV"Lj~=n%8w?C * 0000004159 00000 n 0000009880 00000 n The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. up to 16 weeks can be considered. ____________________________________________________________________________________. 0000102371 00000 n There See section 4. The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. 54 0 obj Please reach out if you have any feedback on the translation. 0000104953 00000 n In clinical trials there were very rare reports of events associated with inflammation of the nervous system, which may cause numbness, pins and needles, and/or loss of feeling. 8 dose multidose vial (4 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. xVN@}W#E{I HTJB+!`)m;:KQyX99se What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. You have rejected additional cookies. If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. Produced in genetically modified human embryonic kidney (HEK) 293 cells. It has been adjusted to work as a delivery system for the vaccine. It is your choice to receive the COVISHIELD . SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. You cannot usually choose which vaccine you have. SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. Oops! In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! Cayman Chemical. In someone age 55 - 59 who is diagnosed with COVID-19, the risks of hospitalization for No substantive data are available related to impact of the vaccine on transmission or viral shedding. 0000056130 00000 n L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. Each vial contains 8 doses of 0.5 ml. 0000097788 00000 n SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. 0000102287 00000 n This is not enough to cause any noticeable effects. 0000085176 00000 n A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. 0000005745 00000 n Dosage level (s) 5 1010 vp (nominal). If you are allergic to any of the active substances or any of the other ingredients listed in section 6. The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. 0000107012 00000 n The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. 0000008003 00000 n 0000098749 00000 n 0000107040 00000 n If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. Dont include personal or financial information like your National Insurance number or credit card details. Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. It should be noted that the full two When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. 0000025064 00000 n In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. Electronic address . trailer , ,p You may need to read it again. endstream endobj 76 0 obj <> stream News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. 818 0 obj <> endobj A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. %%EOF endobj @A20;ia p9I2mL1-bt.S\3=!c`j= y&f" 0M A third injection may be given at least 8 weeks after the second injection if advised by your doctor. 0000004587 00000 n endobj Some cases had a fatal outcome. The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. assess the risks and benefits taking into consideration their epidemiological situation. Page last updated Thursday, May 26, 2022 Read all of this leaflet carefully before the vaccine is given because it contains important information for you. endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. Interim results were published in. AstraZeneca . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Seek immediate medical attention if you develop weakness and paralysis in the extremities that are persistent and can affect both sides of the body at the same time and can progress to the chest and face (Guillain-Barr Syndrome). trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream If you feel unwell after vaccination, do not drive or use machines. One dose (0.5 ml) contains: endstream endobj 549 0 obj <. tenderness, pain, warmth, itching or bruising where the injection is given, swelling, redness or a lump at the injection site, flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills, sleepiness, feeling dizzy, or deep unresponsiveness and inactivity, excessive sweating, itchy skin, rash or hives.