Enemies include Candler, Lil' Haunt, Polty, Red Ghost, Wizoob and The Forsaken, The Haunt, The Heretic and The Rainmaker bosses. The main tear has a roughly 1.71x size multiplier. This may cause you to skip floors where you left a trinket to spawn a Cracked Key. Characters . 2 keys = 16.6% chance. Tears have a 50% chance to be Blood Clot tears. I was incorrect. It is used in the phrase "fire and brimstone" to describe the torments of hell. After reaching level 4 (and at a much lower chance before level 4), Bumbo will also continue to collect coins and drop random pickups, similar to the Bum Friend item, but can also drop pedestal items very rarely. Frozen enemies can be pushed into obstacles where they shatter on contact and fire ice shards around them. Trinkets poison effect for Pestilence, Added as part of the Afterbirth+ Booster Pack #3. The barrage of knives goes all the way across the screen and does not return. The item called Zodiac does not count. Effects Time is the essence", "Sleeping gatekeepers will need to be awoken with a loud sound", UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon). REPENTANCE - Bombs no longer knock each other around when the player has Fast Bombs, allowing for a more controlled line of explosions. Unlocked from the 'Sin Collector' achievement (collect every Bestiary entry), Gulp! Based on the Steam Workshop mod created by by Scayze and Ashkait, *, bloody, paper, script, white, red, toilet paper, seven seals. ?, Satan and The Lamb as Tainted Bethany, Taking damage gives you a chance to spawn a flame orbital, similar to the ones created by Book of Virtues, Entering an Angel Room gives you +5 flame orbitals. Charge time increased to 4 (from 2), UNLOCK: Unlock this item by dying 100 times, * item room, treasure room, item room pool, grey, gray, Holding the active item button will deplete the charge bar. shop item pool, brown, x, cross, paper, Isaac has a random chance to fire another tear out the back of his head, The chance to fire the second tear can improve based on your luck stat and will always activate at +5 Luck, At +0 luck theres a ~50% chance for this effect to activate, Synergizes very well with a lot of items. It bore the . The Lost starts with this item after donating 879 coins to the Greed Donation Machine. Azazel: Overrides Azazel's Brimstone. Curses Fires 3-5 additional beams in random directions around Isaac. Curses It can spawn familiars you haven't unlocked yet! ), Keeps the chance at 100% even after entering and leaving the angel room, meaning the door will not close after visiting, Makes it impossible to find Devil Rooms again, unless you find a way to remove or reroll this item away, or find the Duality item, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Maggy, A sack familiar that drops a sack every 5 or 6 rooms cleared (alternates between 5 and 6), UNLOCK: Unlock this item by defeating Greedier Mode as Cain, * back in black, ac/dc, bag, brown, pouch, pocket, bulge, Gives you an extra heart container for every 25 coins you are currently holding, up to a maximum of 4 extra HP at 99 coins held, If your coin counter goes below the required amount for a heart container, you will lose it again, This item works for the Keeper, allowing him to exceed his usual 2 health containers, However, if Keeper drops to under 2 health coins as a result of Greed's Gullet, he is unable to use a HP Up to increase his health back to 2, and has to regain the lost coins to do so, UNLOCK: Unlock this item by beating Challenge #35 (Pong), *, dollar, cash, sack, bag, pouch, greeds gullet, greed gullet, Gives you a random chance while firing tears to also fire a creep shot, which deals double your tear damage and places white creep on the floor infront of you that slows enemies down if they walk through it, Unlike some similar tear effects, your luck stat does not alter the chance for this effect to activate, A creep shot is also fired in a random direction after taking damage, While firing tears you have a 5% chance to fire a void tear. The damage bonus is unaffected by both positive and negative damage multipliers. ), UNLOCK: Unlock this item by beating Blue Womb (Hush) with Cain, Gives Isaac a familiar golden Censer which creates a huge aura of light that slows down any enemies inside it, UNLOCK: Unlock this item by beating Greed Mode with Maggy, A familiar beggar similar to Bum Friend that follows Isaac and collects keys, giving random chests in return, UNLOCK: Unlock this item by beating Greed Mode with Lazarus, Item Pool: Item Room, Secret Room, Key Beggar, *, grey, gray, black, face, stone, rock, baby, A bag that follows Isaac and drops a random Rune or Soul Stone every 7 or 8 rooms, UNLOCK: Unlock this item by beating the Isaac boss with Lilith, A familiar angel which follows Isaac and fires Sacred Heart tears which deal 10 damage at -25% shot speed and a reduced fire rate, Item Pool: Item Room, Angel Room, Greed Mode Angel Room, This item causes enemy projectiles to be able to hit other enemies. Isaac doesn't take damage from this effect, UNLOCK: Unlock this item by defeating Delirium as Tainted Lost, Spawns a familiar that's attached via an Umbilical Cord, but will move and shoot in the same direction Isaac is shooting, When activated you first need to throw the familiar, which deals x3 your tear damage to any enemies it touches, Gello's tears deal x0.75 your tear damage (x1.0 if Lilith), Can be used multiple times per room to spawn more familiars, however they only last for the current room, UNLOCK: Unlock this item by defeating Delirium as Tainted Lilith, When used, this item allows you to throw your head where it will sit as a stationary sentry firing bullets until you walk over and pick it up again, Throwing Isaac's head deals 24 damage to anything it hits while being thrown, Your hitbox remains with the body. the lost item pool, brown, white, cross, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection, white, A beggar who follows Isaac around and automatically picks up nearby coins, After picking up 6 coins he will drop a random pickup, e.g. Taking a Devil deal breaks the cross and prevents the damage up next floor, Taking free pickups such as Black hearts in the Devil room also count, UNLOCK: Unlock this item by defeating The Beast as Judas, When you die, you turn into a ghost with 1/2 a red heart and flying, that is chained to your body for 10 seconds. A slow pulsing outline HUD effect appears for cards that would be buffed by Tarot Cloth, To see the full list of Tarot Card effects, check out the Mechanics > Tarot Cloth page, Every time you take damage, 10 high damage tears are fired in a circle around you (similar to the Tammy's Head effect), Tear damage is equal to Isaac's tear damage + 25 flat damage, Additionally, has a chance to activate the Anemic effect when taking damage for 2 seconds, Similar to Tammy's Head, this item synergizes with a lot of items (i.e. REPENTANCE - Bob's Brain now has an increased delay before becoming available when entering rooms. The more you spend the higher the stat increase, Possible stats include Speed, Damage and Range, 15c items give all 3 stats: +1 Damage Up, +0.03 or +0.06 Speed Up, +0.25 or +0.5 Range Up, 5c items give 1 or 2 stats: +0.5 Damage Up **OR** +0.25 Range and +0.03 Speed Up, UNLOCK: Unlock this item by defeating Mother as The Keeper, While in a room with enemies, blue spiders will randomly spawn from objects in the room (e.g. shop room pool, shop item pool,red, robot, head, cube, REPENTANCE - This item has been reworked. purple, An orbiting fly which deals 2 contact damage per tick to enemies, * item room, treasure room, item room pool, blue, Has a chance to drop from the Super Gluttony miniboss fight, Item Pool: Item Room, Super Gluttony Miniboss, * item room, treasure room, item room pool, the lost item pool, white, grey, gray, tub, Allows Isaac to fly while the Pony is held, Sets your speed stat to 1.5 if it isn't already that high, When the active attack is used, Isaac will dash across the screen dealing scaling contact damage to anything he hits, Drops from the Headless Horseman boss fight, REPENTANCE - A Pony's charge time has been reduced to 2 (from 4). UNLOCK: Unlock this item by defeating Delirium in The Void floor with Isaac, A one time use active item that when used, will spawn 2 random item pedestals from the item pool associated with the current room (e.g. This item has two styles, named "Hat" and "No Hat".The "Hat" style retains the default headgear, while the "No Hat" style hides it.. Broken hearts permanently subtract from your total possible health containers, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Magdalene, Isaac turns to stone and can't move for 10 seconds, but your tear rate goes up significantly for the duration, UNLOCK: Unlock this card by defeating challenge #42 (Hot Potato), UNLOCK: Unlock this card by defeating challenge #43 (Cantripped), "May you see the value of all things in life", When used, all items and pickups in the current room are turned into money. Bosses These ticks occur every 1/15th of a second (once every 4 frames). Based on the Steam Workshop mod created by Ratlah, UNLOCK: Unlock this item by sleeping in 10 different beds, When used, this item will sacrifice up to 2 of your familiars (chosen at random), and spawn a random Devil Room item for each familar sacrificed this way, In addition to the familiars, any blue flies or spiders will be converted to 1 coin each, If Guardian Angel, Sworn Protector, or Seraphim is sacrificed, Satan will be extra happy and reward you with 2 black hearts, Incubus won't be sacrificed if you're playing as Lilith, If used while you have no familiar, this item will do nothing and won't consume the item, Added as part of the Afterbirth+ Booster Pack #5. ?, Satan and The Lamb as Tainted Lost. Release Brimstone and tap multiple times in the direction Isaac fired. Hook Worm, Wiggle Worm etc. From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac. Only contact poison has this effect - poison from tears doesn't work, UNLOCK: Unlock this item by beating Satan with Lilith, *, green, lips, kiss, drip, drop, serpents kiss, serpent kiss, Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player, This allows for a full 360 degree tear firing radius, Can be overridden by other tear modifiers such as Mom's Knife or Brimstone, Every time you leave the room this effect turns off until you press a shoot button again, Tears are replaced with the ability to charge and fire a laser ring that travels across the room, The size of the ring will depend on how long you charge it, The laser ring does damage scaling based on charge, from 25% at minimum to 100% at max, Rings have infinite range and travel until they hit a wall, Multiple Tech X stacks - every one taken adds another laser ring (doesn't affect your fire rate), * tech 10, tech ten, donut laser rings, vr, headset, visor, Allows you to create one brown tunnel and one blue tunnel in the floor, that can be used to teleport between wherever you placed each one, This item will let you port out of the devil room but not back into it, Very useful in the boss rush and challenge rooms, *, scalpel, red, silver, white, grey, gray, metal, knife, cut, Isaac's tears now travel directly forwards following a beam of light, but will also move sideways based on your player movement, Allows for more accurate correction when firing tears, as their direction can be controlled even after they have been fired, If you switch the direction in which you are firing tears, the beam of light and all your tears will also be transported to the new direction, Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size for 5 seconds and also run away from Isaac, Shrunk enemies can be crushed and killed by walking over them, After firing tears for 3 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring which deals a lot of damage to any enemies inside it, The ring deals damage equal to your tear damage rapidly to any enemies in contact with it, for a total of 30 ticks of damage, You have to keep the fire button held down for the full 3 seconds to cause this effect, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Azazel, In addition to tears, Isaac now holds a spear infront of him which deals damage equal to 2 times your tear damage. REPENTANCE - White poop from Hallowed Ground is now more durable, similar to golden poop. Manage all your favorite fandoms in one place! Item Pool: Item Room, Super Sloth Miniboss, Bomb Beggar, * boss rush pool, boss rush room, item room, treasure room, item room pool, bob sloth, with Brimstone it fires 10 lasers), Turns your tears into bones, which shatter into 1-3 smaller bone shards upon hitting any object or enemy, The smaller bone shards deal damage equal to half your normal tear damage, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Lazarus, Allows Isaac to carry two cards, runes or pills (or any combination of these) at the same time, Drops a random card, pill or rune on pickup, UNLOCK: Unlock this item by beating Greedier Mode with The Lost, Item Pool: Boss Room, Beggar, Gold/Stone Chest, *, silver, metal, grey, gray, omega, dads lost coin, dad lost coin, dad coin, REPENTANCE - This was renamed from Moldy Bread, *, sandwich, toast, brown, green, bite, bitten, Each time you take damage from any source, Cone Head has a 20% chance to prevent it from reducing your health, Isaac flashes blue very briefly when damage is negated by this item, * northernlion, nl, northern lion, ryan letourneau, egg, egg father, egg daddy, dad, BALD, northernlion's head resembles an egg much like this item, isn't that hilarious?, pink, Isaac's tears have a 20% chance to be a booger instead, which stick on to enemies and deal periodic poison damage until they die, Each tick of poison damage is equal to your normal tear damage, Each booger persists for 10 seconds or until the enemy dies. 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